Association between ¹⁸F – FDG uptake and global cognitive performance in individuals at risk of dementia

Background Cardiometabolic disorders (CMD) and Mild Cognitive Impairment (MCI) have been associated with an increased risk of developing dementia. However, brain glucose metabolism has not compared between patients CMD MCI, little is known about its associations global cognitive performance. Here we examined regional 18F – FDG uptake in analyzed potential Methods 55 for dementia were recruited (MCI = 22; 33) this cross-sectional study. As a measure metabolism, PET/CT was performed the mean value regions interest (ROI) obtained standardized by whole uptake. Global performance using Mini-Mental State Examination (MMSE). Group differences examined. We conducted separate linear regression models considering MMSE as dependent variable, each ROI (and CMD/MCI group-interactions) independent variables. Our adjusted age, gender, years education, presence at least one APOE e4 allele, corrected multiple testing False Discovery Ratio (FDR < 0.01). Results The MCI groups comparable 18F-FDG across all ROIs, but significantly different (Table 1). Adjusted showed significant group interactions bilateral caudate hippocampus, well left-hemisphere amygdala, cuneus, fusiform gyrus, opercular part inferior frontal gyrus. Thus, negative above ROIs observed (Figure 1 & Table 2). Conclusions In patients, reduced high left gyrus (opercular part). These asymmetric low could suggest compensatory effects further research needed to confirm hypothesis.